Tris[2-(Acryloyloxy)Ethyl]Isocyanurate Cross-Linked PolyethylenimineEnhanced Exon-Skipping of Antisense 2′-Omethyl PhosphorothioateOligonucleotide in vitro and in vivo

  title={Tris[2-(Acryloyloxy)Ethyl]Isocyanurate Cross-Linked PolyethylenimineEnhanced Exon-Skipping of Antisense 2′-Omethyl PhosphorothioateOligonucleotide in vitro and in vivo},
  author={Mingxing Wang and Bo Wu and Jason D Tucker and Peijuan Lu},
  journal={Journal of Nanomedicine \& Nanotechnology},
Branched poly(ester amine)s (PEAs) based on tris[2-(acryloyloxy)ethyl]isocyanurate (TAEI) cross-linked low molecular weight polyethylenimine (LPEI, Mw: 0.8k/1.2k/2.0k) polymers have been evaluated for their ability to deliver antisense 2′-O-methyl phosphorothioate RNA (2′-OMePS) through in vitro and in dystrophic mdx mice. Almost all PEAs improved exon-skipping of 2′-OMePS both in vitro and in vivo. Especially the PEAs composed of PEI 2.0k (C series) enhanced 2′-OMePS delivery more effectively… Expand

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