Tris(2-chloroethyl)phosphate-induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway.

@article{Zhang2016Tris2chloroethylphosphateinducedCG,
  title={Tris(2-chloroethyl)phosphate-induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway.},
  author={Wenjuan Zhang and Youjian Zhang and Zhiyuan Wang and Tian Xu and Chen Huang and Wenjun Yin and Jing Wang and Wei Xiong and Wenhong Lu and Hongyan Zheng and Jing Yuan},
  journal={Journal of applied toxicology : JAT},
  year={2016},
  volume={36 7},
  pages={914-24}
}
Tris(2-chloroethyl)phosphate (TCEP) as an organophosphorus flame retardant and plasticizer has been widely used in industrial and household products. It not only was detected in residential indoor air and dust, surface and drinking water, but also in human plasma and breast milk, and tissue samples of liver, kidneys and brain from rodents. TCEP is classified as carcinogenic category 2 and toxic for reproduction category 1B. Sufficient evidence from experimental animals indicated carcinogenicity… CONTINUE READING