Triptolide reverses hypoxia-induced epithelial–mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation

@inproceedings{Liu2014TriptolideRH,
  title={Triptolide reverses hypoxia-induced epithelial–mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation},
  author={Li Liu and Alexei V. Salnikov and Nathalie Bauer and Ewa Aleksandrowicz and Sabrina Labsch and Clifford C. Nwaeburu and Juergen Mattern and Jury Gladkich and Peter Schemmer and Jens Werner and Ingrid Herr},
  booktitle={International journal of cancer},
  year={2014}
}
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies characterized by an intense tumor stroma with hypoperfused regions, a significant inflammatory response and pronounced therapy resistance. New therapeutic agents are urgently needed. The plant-derived agent triptolide also known as "thunder god vine" has a long history in traditional Chinese medicine for treatment of rheumatoid arthritis and cancer and is now in a clinical phase II trial for establishing the efficacy… CONTINUE READING
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