Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA

@article{Visp2009TriptolideIA,
  title={Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA},
  author={St{\'e}phane Visp{\'e} and L. Devries and Laurent Créancier and J{\'e}r{\^o}me Besse and Sophie Br{\'e}and and David J. Hobson and Jesper Q. Svejstrup and Jean-Philippe Annereau and Didier Cussac and Charles Dumontet and Nicolas Guilbaud and Jean Marc Barret and Christian Bailly},
  journal={Molecular Cancer Therapeutics},
  year={2009},
  volume={8},
  pages={2780 - 2790}
}
Triptolide, a natural product extracted from the Chinese plant Tripterygium wilfordii, possesses antitumor properties. Despite numerous reports showing the proapoptotic capacity and the inhibition of NF-κB–mediated transcription by triptolide, the identity of its cellular target is still unknown. To clarify its mechanism of action, we further investigated the effect of triptolide on RNA synthesis in the human non–small cell lung cancer cell line A549. Triptolide inhibited both total RNA and… Expand
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The results show that triptolide triggers a CDK7-mediated degradation of RNAPII that may offer an explanation to many of its therapeutic properties, including its robust and promising anticancer properties. Expand
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It is reported that triptolide covalently binds to human XPB, a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II-mediated transcription and likely nucleotide excision repair. Expand
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Triptolide Inhibits MDM2 and Induces Apoptosis in Acute Lymphoblastic Leukemia Cells through a p53-Independent Pathway
TLDR
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Triptolide Inhibits MDM 2 and Induces Apoptosis in Acute Lymphoblastic Leukemia Cells through a p 53-Independent Pathway
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Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1.
TLDR
Triptolide-induced apoptosis in myeloma cells is associated with the loss of mitochondrial transmembrane potential, the release of cytochrome c and Smac/DIABLO from mitochondria into the cytosol, and the activation of caspases-3 and caspase-9. Expand
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TLDR
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