Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.

@article{Visp2009TriptolideIA,
  title={Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.},
  author={St{\'e}phane Visp{\'e} and Luc DeVries and Laurent Cr{\'e}ancier and J{\'e}r{\^o}me Besse and Sophie Br{\'e}and and David J. Hobson and Jesper Qualmann Svejstrup and Jean-Philippe Annereau and Didier Cussac and Charles Dumontet and Nicolas Guilbaud and J Carl Barret and Christian Bailly},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 10},
  pages={2780-90}
}
Triptolide, a natural product extracted from the Chinese plant Tripterygium wilfordii, possesses antitumor properties. Despite numerous reports showing the proapoptotic capacity and the inhibition of NF-kappaB-mediated transcription by triptolide, the identity of its cellular target is still unknown. To clarify its mechanism of action, we further investigated the effect of triptolide on RNA synthesis in the human non-small cell lung cancer cell line A549. Triptolide inhibited both total RNA and… CONTINUE READING
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