Corpus ID: 57552496

Triptolide induces apoptosis of rat synoviocytes in collagen- induced arthritis

  title={Triptolide induces apoptosis of rat synoviocytes in collagen- induced arthritis},
  author={Tu Sheng-hao and Huang Yonghong and Weng Geng-min and Lu Fu-er and Zhang Ming-min and Lai Xian-yang and Liu Peilin},
  journal={Chinese Journal of Pathophysiology},
AIM: To determine whether triptolide induce apoptosis of synovial cells in collagen-induced arthritis (CIA) in rats. METHODS: The male Wistar rats were used to make CIA models by immunized with Bovine collagen Ⅱ (BCⅡ) in Freund's complete adjuvant (FCA). A total of 20 CIA rats were randomly divided into 2 groups, triptolide group (10 rats) and CIA control group (10 rats). Triptolide group were administered with triptolide at 40 μg/kg body weight intramuscularly every three days. CIA control… Expand

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