Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway.

@article{Kim2010TriptolideIA,
  title={Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway.},
  author={Min Jung Kim and Tae Hwa Lee and Sung Han Kim and Yeon-Joo Choi and Jeonghoon Heo and Youngho Kim},
  journal={International journal of oncology},
  year={2010},
  volume={37 5},
  pages={1177-85}
}
Triptolide, the main active component of the traditional Chinese herbal medicine Tripterygium wilfordii Hook F, has been shown to have potent immunosuppressive and anti-inflammatory properties. Here, we investigated the pro-apoptotic effect of triptolide in human cervical cancer cells and its underlying mechanisms. Exposure of cervical cancer cells to triptolide induced apoptosis, which was accompanied by loss of mitochondrial membrane potential, caspase processing (caspase-8, -9 and -3), and… CONTINUE READING