Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells

@article{Klawitter2011TriptolideEA,
  title={Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells},
  author={Marina Klawitter and Lilian Quero and Juergen Klasen and Thomas Liebscher and Andreas Nerlich and Norbert Boos and Karin Wuertz},
  journal={European Spine Journal},
  year={2011},
  volume={21},
  pages={850-859}
}
Increased levels of proinflammatory cytokines seem to play a pivotal role in the development of back pain in a subpopulation of patients with degenerative intervertebral disc (IVD) disease. As current treatment options are mostly limited to surgical interventions or conservative treatment, anti-inflammatory substances might offer a novel, more target-orientated therapeutic approach. Triptolide (TPL), a natural substance found in the Chinese medicinal herb Tripterygium wilfordii Hook, has been… CONTINUE READING
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