Triptolide down-regulates bcr-abl expression and induces apoptosis in chronic myelogenous leukemia cells.

@article{Lou2004TriptolideDB,
  title={Triptolide down-regulates bcr-abl expression and induces apoptosis in chronic myelogenous leukemia cells.},
  author={Yinjun Lou and Jie Jin},
  journal={Leukemia & lymphoma},
  year={2004},
  volume={45 2},
  pages={373-6}
}
Interest in exploiting traditional medicines for prevention or treatment of cancer is increasing. Extracts from the herb Tripterygium wilfordii hook F have been used in China for centuries to treat immune-related disorders. Recently it was reported that triptolide, a purified compound from Tripterygium, possessed antitumor properties and induced apoptosis in a variety of malignant cell lines. K562 cells are usually resistant to apoptosis induction, probably because of the expression of bcr-abl… CONTINUE READING