Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma.

@article{Clawson2010TriptolideAT,
  title={Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma.},
  author={Kimberly A. Clawson and Daniel Borja–Cacho and Mara B. Antonoff and Ashok Kumar Saluja and Selwyn Vickers},
  journal={The Journal of surgical research},
  year={2010},
  volume={163 2},
  pages={
          244-9
        }
}
BACKGROUND Cholangiocarcinoma originates from bile duct epithelial cells in the intrahepatic and extrahepatic biliary system. We recently observed that triptolide (a diterpenoid triepoxide) is effective in inducing apoptosis in pancreatic tumors. Death receptors 4 and 5 are overexpressed in several cancer types, and their activation by tumor-necrosis factor-related apoptosis-inducing ligand (TRAIL) induces cell death. The principal objective of this study was to determine the effects of… CONTINUE READING

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