Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation

@article{Li2004TriptolideAC,
  title={Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation},
  author={Feng-qiao Li and Xiu-Zhi Lu and Xiaozhu Liang and Huifang Zhou and Xiaomin Wang},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={148},
  pages={24-31}
}
Mounting lines of evidence have suggested that brain inflammation participates in the pathogenesis of Parkinson's disease. Triptolide is one of the major active components of Chinese herb Tripterygium wilfordii Hook F, which possesses potent anti-inflammatory and immunosuppressive properties. We found that triptolide concentration-dependently attenuated the lipopolysaccharide (LPS)-induced decrease in [3H]dopamine uptake and loss of tyrosine hydroxylase-immunoreactive neurons in primary… CONTINUE READING
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