Triptans (Serotonin, 5-HT1B/1D Agonists) in Migraine: Detailed Results and Methods of A Meta-Analysis of 53 Trials

@article{Ferrari2002Triptans5,
  title={Triptans (Serotonin, 5-HT1B/1D Agonists) in Migraine: Detailed Results and Methods of A Meta-Analysis of 53 Trials},
  author={Mat{\'i}as Ferrari and P Goadsby and KI Roon and R. B. Lipton},
  journal={Cephalalgia},
  year={2002},
  volume={22},
  pages={633 - 658}
}
The triptans, selective serotonin 5-HT1B/1D agonists, are very effective acute migraine drugs. [] Key Method We asked pharmaceutical companies and the principal investigators of company-independent trials for the ‘raw patient data’ of all double-blind, randomized, controlled, clinical trials with oral triptans in migraine. All data were cross-checked with published or presented data.

A review of rizatriptan, a quick and consistent 5-HT1B/1D agonist for the acute treatment of migraine

  • J. Pascual
  • Medicine
    Expert opinion on pharmacotherapy
  • 2004
Control head-to-head data and a meta-analysis of 53 randomised, placebo-controlled trials of oral triptans in > 24,000 patients have shown that rizatriptan 10 mg offers efficacy advantages over oral sumatripta 50 and 100 mg and other oral triPTans, both in terms of speed of onset of action and consistency.

Double-Blind Clinical Trials of Oral Triptans Vs Other Classes of Acute Migraine Medication — A Review

It is found that experience in clinical practice suggests that, for many patients, oral triptans are superior to non-specific acute treatments, creating a discrepancy between clinical trials results and clinical practice experience.

New Agents for Acute Treatment of Migraine: CGRP Receptor Antagonists, iNOS Inhibitors

Results from studies with BI 44370 TA do not support broad concern about a class effect, and further studies are ongoing in this respect, suggesting that iNOS is very unlikely to be a promising target.

Safety and Efficacy of Ubrogepant for the Acute Treatment of Episodic Migraine: A Meta-Analysis of Randomized Clinical Trials

The use of ubrogepant as an acute treatment of episodic migraine in adults led to a greater percentage of freedom from pain and absence of the most bothersome symptoms at 2 h post-dose and was not related to an increased risk for adverse events.

Drugs targeting 5-hydroxytryptamine receptors in acute treatments of migraine attacks. A review of new drugs and new administration forms of established drugs

None of these reviewed treatments are likely to fulfill patients' expectations, and the advancement of acute migraine drugs should likely depend on different mechanisms from current 5-HT-related drugs.

Lasmiditan for Acute Treatment of Migraine in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials

In this meta-analysis, the use of lasmiditan as an acute treatment for episodic migraine in adults led to a greater percentage of freedom of pain and the absence of the most bothersome symptoms at 2 h post-dose.
...

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