Triplex targets in the human rhodopsin gene.

  title={Triplex targets in the human rhodopsin gene.},
  author={Brian D Perkins and J. H. P. Wilson and Theodore G Wensel and Karen M. Vasquez},
  volume={37 32},
We have explored the application of triplex technology to the human rhodopsin gene, which encodes a G-protein-linked receptor involved in the genetic disorder autosomal dominant retinitis pigmentosa (ADRP). Our results support the hypothesis that most human genes contain high-affinity triplex sites and further refine the rules governing identification and successful targeting of triplex-forming oligonucleotides (TFOs) to these sites. Using a computer search for sites 15 nucleotides in length… CONTINUE READING

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