Triplex formation by oligonucleotides containing 5-(1-propynyl)-2'-deoxyuridine: decreased magnesium dependence and improved intracellular gene targeting.

@article{Lacroix1999TriplexFB,
  title={Triplex formation by oligonucleotides containing 5-(1-propynyl)-2'-deoxyuridine: decreased magnesium dependence and improved intracellular gene targeting.},
  author={Laurent Lacroix and J{\'e}r{\^o}me Lacoste and James F Reddoch and Jean-Louis Mergny and Dan D. Levy and Michael M. Seidman and M. D. Matteucci and Peter M. Glazer},
  journal={Biochemistry},
  year={1999},
  volume={38 6},
  pages={1893-901}
}
Oligonucleotides capable of sequence-specific triple helix formation have been proposed as DNA binding ligands useful for modulation of gene expression and for directed genome modification. However, the effectiveness of such triplex-forming oligonucleotides (TFOs) depends on their ability to bind to their target sites within cells, and this can be limited under physiologic conditions. In particular, triplex formation in the pyrimidine motif is favored by unphysiologically low pH and high… CONTINUE READING

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