Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology.

@article{Desai2009TripletransgenicAD,
  title={Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology.},
  author={Maya K Desai and Kelly L Sudol and Michelle Christine Janelsins and Michael A. Mastrangelo and Maria E. Frazer and William J. Bowers},
  journal={Glia},
  year={2009},
  volume={57 1},
  pages={54-65}
}
Alzheimer's disease (AD) is a progressively debilitating brain disorder pathologically defined by extracellular amyloid plaques, intraneuronal neurofibrillary tangles, and synaptic disintegrity. AD has not been widely considered a disease of white matter, but more recent evidence suggests the existence of abnormalities in myelination patterns and myelin attrition in AD-afflicted human brains. Herein, we demonstrate that triple-transgenic AD (3xTg-AD) mice, which harbor the human amyloid… CONTINUE READING

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