Triple recognition of B-DNA by a neomycin-Hoechst 33258-pyrene conjugate.

Abstract

Recent developments have indicated that aminoglycoside binding is not limited to RNA, but to nucleic acids that, like RNA, adopt conformations similar to its A-form. We further sought to expand the utility of aminoglycoside binding to B-DNA structures by conjugating neomycin, an aminoglycoside antibiotic, with the B-DNA minor groove binding ligand Hoechst… (More)
DOI: 10.1021/bi9016796

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@article{Willis2010TripleRO, title={Triple recognition of B-DNA by a neomycin-Hoechst 33258-pyrene conjugate.}, author={Bert Willis and Dev P Arya}, journal={Biochemistry}, year={2010}, volume={49 3}, pages={452-69} }