Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer

@inproceedings{Phuah2012TriplenegativeBC,
  title={Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer},
  author={Sze Yee Phuah and Lai-Meng Looi and Norhashimah Hassan and A Rhodes and Sarah J R Dean and Nur Aishah Mohd Taib and Cheng-Har Yip and Soo Hwang Teo},
  booktitle={Breast Cancer Research},
  year={2012}
}
Given that breast cancers in germline BRCA1 carriers are predominantly estrogen-negative and triple-negative, it has been suggested that women diagnosed with triple-negative breast cancer (TNBC) younger than 50 years should be offered BRCA1 testing, regardless of family cancer characteristics. However, the predictive value of triple-negative breast cancer, when taken in the context of personal and family cancer characteristics, is unknown. The aim of this study was to determine whether TNBC is… CONTINUE READING
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