Triple-negative breast cancer: molecular subtypes and targeted therapy.

  title={Triple-negative breast cancer: molecular subtypes and targeted therapy.},
  author={Kim M. Hirshfield and Shridar Ganesan},
  journal={Current opinion in obstetrics & gynecology},
  volume={26 1},
PURPOSE OF REVIEW Triple-negative breast cancers (TNBCs), lacking estrogen receptor expression and human epidermal growth factor receptor 2 amplification, have no effective targeted therapy. Large-scale comprehensive genomic analyses have allowed stratification of TNBCs by molecular features. We will review the recent data regarding the classification of these poor prognosis cancers and the associated potential targeted treatment approaches. RECENT FINDINGS TNBCs are a heterogeneous set of… CONTINUE READING


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