Triple helix formation at distant sites: hybrid oligonucleotides containing a polymeric linker.

Abstract

An oligonucleotide hybrid is described which possesses two triple helix forming oligonucleotides which have been connected by a flexible polymeric linker chain. As a prototype, binding of this class of oligonucleotide to duplex DNA has been studied using a segment of the HSV-1 D-glycoprotein promoter, which possesses a pair of 12bp target sites for stable… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.