Triple-controlled oncolytic adenovirus expressing melittin to exert inhibitory efficacy on hepatocellular carcinoma.

@article{Qian2015TriplecontrolledOA,
  title={Triple-controlled oncolytic adenovirus expressing melittin to exert inhibitory efficacy on hepatocellular carcinoma.},
  author={Chun-Yu Qian and Kai-li Wang and Fan-fu Fang and Wei Gu and Feng Huang and Fu-zhe Wang and Bai Li and Li-na Wang},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 9},
  pages={
          10403-11
        }
}
Hepatocellular carcinoma (HCC) is a highly malignant disease, and its outcome of routine therapies is poor. Comprehensive treatment including gene therapy is an important way to improve patients' prognosis and survival. In this study, we successfully constructed a triple-controlled cancer-selective oncolytic adenovirus, QG511-HA-Melittin, carrying melittin gene, in which the hybrid promoter, hypoxia-response element (HRE)-AFP promoter, was used to control viral E1a expression targeting AFP… CONTINUE READING

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