Triple approach for diagnosis and grading of meningiomas: Histology, morphometry of Ki-67/feulgen stainings, and cytogenetics

@article{Kolles1995TripleAF,
  title={Triple approach for diagnosis and grading of meningiomas: Histology, morphometry of Ki-67/feulgen stainings, and cytogenetics},
  author={Harry Kolles and I. S. P. Daryle Niedermayer and Ch. Schmitt and Wolfram Henn and Ronald Feld and Wolf Ingo Steudel and Klaus Dieter Zang and Wolfgang Feiden},
  journal={Acta Neurochirurgica},
  year={1995},
  volume={137},
  pages={174-181}
}
With regard to meningioma grading and the recently introduced “atypical” meningioma, we evaluated 160 cases retrospectively by conventional histology and image analysis. For that, the cell nuclei were stained with a Ki-67 (MIB1)/Feulgen-method on paraffin sections, thus enabling the assessment of both the Ki-67 proliferation index and nuclear morphometric features, such as tumour cell arrangement, nuclear pleomorphism, and cellularity. It could be demonstrated that the Ki-67 proliferation index… CONTINUE READING

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