Triple Therapy Greatly Increases Myocardial Salvage During Ischemia/Reperfusion in the in situ Rat Heart

@article{Yang2013TripleTG,
  title={Triple Therapy Greatly Increases Myocardial Salvage During Ischemia/Reperfusion in the in situ Rat Heart},
  author={Xi-ming Yang and Lin Cui and Ahmad T. Alhammouri and James M. Downey and Michael V. Cohen},
  journal={Cardiovascular Drugs and Therapy},
  year={2013},
  volume={27},
  pages={403-412}
}
Cangrelor, a P2Y12 receptor blocker, administered just prior to reperfusion reduced but did not eliminate myocardial infarction in rabbits. Combining cangrelor with ischemic postconditioning offered no additional protection suggesting they protected by a similar mechanism. To determine if cangrelor’s protection might be additive to other cardioprotective interventions we tested cangrelor in combination with ischemic preconditioning, cariporide, a sodium-hydrogen exchange blocker, and mild… CONTINUE READING
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