Triphenyl phosphite-induced impairment of spatial alternation learning.

  title={Triphenyl phosphite-induced impairment of spatial alternation learning.},
  author={E D Levin and N Channelle Christopher and Mohamed Bahie Abou-Donia},
  journal={Journal of toxicology and environmental health},
  volume={44 4},
Triphenyl phosphite (TPP) is a weak acetylcholinesterase inhibitor and a type II organophosphorus compound-induced delayed neurotoxic agent. The current study examined the cognitive effects of a single 250 mg/kg ip dose of TPP administered to either 3-mo- or 1-yr-old male Sprague-Dawley rats. Starting 4 d after TPP administration, the rats began training on a T-maze spatial alternation task for food reinforcement. Over five sessions of acquisition training, the TPP-treated rats showed… CONTINUE READING


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