Triphasic force dependence of E-selectin/ligand dissociation governs cell rolling under flow.

@article{Wayman2010TriphasicFD,
  title={Triphasic force dependence of E-selectin/ligand dissociation governs cell rolling under flow.},
  author={Annica M. Wayman and Wei Chen and Rodger P McEver and Cheng Zhu},
  journal={Biophysical journal},
  year={2010},
  volume={99 4},
  pages={
          1166-74
        }
}
  • Annica M. Wayman, Wei Chen, +1 author Cheng Zhu
  • Published in Biophysical journal 2010
  • Chemistry, Medicine
  • During inflammation, flowing leukocytes tether to and roll on vascular surfaces through the association and dissociation of selectin/ligand bonds. The interactions of P- and L- selectins with their respective ligands exhibit catch-slip bonds, such that increasing force initially prolongs and then shortens bond lifetimes. In addition, catch-slip bonds have been shown to govern L-selectin-mediated cell rolling. Using a flow chamber and biomembrane force probe, we show a triphasic force dependence… CONTINUE READING

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