Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination.

@article{Li2011TripartiteM8,
  title={Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination.},
  author={Qi Li and Jie Yan and Ai-Ping Mao and Chao Li and Yong Ran and Hong-Bing Shu and Yan-Yi Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 48},
  pages={19341-6}
}
The tripartite motif (TRIM)-containing proteins are a family of proteins that have been known to be involved in divergent biological processes, including important roles in immune responses through regulating various signaling pathways. In this study, we identified a member of the TRIM family, TRIM8, as a positive regulator of tumor necrosis factor-α (TNFα) and interleukin-1β (IL-1β)-triggered NF-κB activation. Overexpression of TRIM8 activated NF-κB and potentiated TNFα- and IL-1β-induced… CONTINUE READING
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