Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae.

  title={Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae.},
  author={Elton T. Young and James S. Sloan and Kristen van Riper},
  volume={154 3},
The genome of Saccharomyces cerevisiae contains numerous unstable microsatellite sequences. Mononucleotide and dinucleotide repeats are rarely found in ORFs, and when present in an ORF are frequently located in an intron or at the C terminus of the protein, suggesting that their instability is deleterious to gene function. DNA trinucleotide repeats (TNRs) are found at a higher-than-expected frequency within ORFs, and the amino acids encoded by the TNRs represent a biased set. TNRs are rarely… CONTINUE READING
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