Trinucleotide repeat instability during double-strand break repair: from mechanisms to gene therapy

@article{Mosbach2018TrinucleotideRI,
  title={Trinucleotide repeat instability during double-strand break repair: from mechanisms to gene therapy},
  author={Valentine Mosbach and Lucie Poggi and Guy-Franck Richard},
  journal={Current Genetics},
  year={2018},
  volume={65},
  pages={17-28}
}
Trinucleotide repeats are a particular class of microsatellites whose large expansions are responsible for at least two dozen human neurological and developmental disorders. Slippage of the two complementary DNA strands during replication, homologous recombination or DNA repair is generally accepted as a mechanism leading to repeat length changes, creating expansions and contractions of the repeat tract. The present review focuses on recent developments on double-strand break repair involving… 

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