Trimming of two major type 1 diabetes driving antigens, GAD65 and IA-2, allows for successful expression in Lactococcus lactis.

@article{Robert2015TrimmingOT,
  title={Trimming of two major type 1 diabetes driving antigens, GAD65 and IA-2, allows for successful expression in Lactococcus lactis.},
  author={Sofie Robert and Karolien van Huynegem and Conny A. Gysemans and Chantal Mathieu and Pieter Rottiers and Lothar Steidler},
  journal={Beneficial microbes},
  year={2015},
  volume={6 4},
  pages={591-601}
}
Type 1 diabetes (T1D) is a chronic autoimmune disease characterised by excessive immune reactions against auto-antigens of pancreatic β-cells. Restoring auto-antigen tolerance remains the superior therapeutic strategy. Oral auto-antigen administration uses the tolerogenic nature of the gut-associated immune system to induce antigen-specific tolerance… CONTINUE READING