Trimipramine: A challenge to current concepts on antidepressives

@article{Berger2005TrimipramineAC,
  title={Trimipramine: A challenge to current concepts on antidepressives},
  author={M. Berger and Markus Gastpar},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2005},
  volume={246},
  pages={235-239}
}
  • M. Berger, M. Gastpar
  • Published 2005
  • Psychology, Medicine
  • European Archives of Psychiatry and Clinical Neuroscience
Although it is chemically a classical tricyclic antidepressant agent, trimipramine shows atypical pharmacological properties. Its well-documented antidepressant action cannot be explained by noradrenaline or serotonin reuptake inhibition or by a down-regulation of β-adrenoceptors. Furthermore, its receptor affinity profile resembles more that of clozapine, a neuroleptic drug, than that of tricyclic antidepressants. Trimipramine does not reduce, but rather increases, rapid eye movement sleep. It… 
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