Trimipramine, Anxiety, Depression and Sleep

@article{Pecknold2012TrimipramineAD,
  title={Trimipramine, Anxiety, Depression and Sleep},
  author={John C. Pecknold and Lorenz Luthe},
  journal={Drugs},
  year={2012},
  volume={38},
  pages={25-31}
}
SummaryThe presence of mixed symptoms of anxiety and depression are well known to every clinician. Panic, generalised anxiety and obsessive-compulsive disorder all have considerable overlap with major depressive illness. Factor analysis of anxiety and depression symptoms has sought to predict response to treatment as well as to establish a diagnosis. Sleep disturbances are important concomitants of both syndromes. The analysis of the architecture and phasing of sleep stages has been proposed as… 
1 Citations
Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning.
TLDR
It is demonstrated that moderate trimipramine poisoning can already occur after ingestion of doses in the high therapeutic range, and poisoned patients have to be monitored for central nervous system depression, dysrhythmias and QT(c) prolongation.

References

SHOWING 1-10 OF 52 REFERENCES
Anxiety syndromes and their relationship to depressive illness.
TLDR
Analysis by depressive subtypes showed no differences for the bipolar/unipolar distinction, but significant differences in anxiety symptoms were seen in the primary vs. secondary and, more strikingly, endogenous vs. nonendogenous categories.
Panic disorder and major depression. A tale of two syndromes.
  • M. Stein, T. Uhde
  • Psychology, Medicine
    The Psychiatric clinics of North America
  • 1988
TLDR
A conceptualization of panic disorder and major depression as nonidentical disorders with many shared characteristics is favored, to eventually lead to a clearer demarcation of the boundaries between these two intriguing psychiatric syndromes.
Effects on sleep: a double-blind study comparing trimipramine to imipramine in depressed insomniac patients.
TLDR
The data demonstrate that antidepressants may vary in their effects on sleep, even though they have similar effects on depression; REM sleep suppression does not necessarily accompany improvement in depression; and reports of improved sleep by patients undergoing antidepressant therapy may not reflect improvement on objective measures of sleep.
Cholinergic REM induction response: Separation of anxiety and depression
TLDR
The use of biological markers in differentiating between clinical syndromes confounded by mixed or overlapping phenomenology is highlighted, and there was considerable overlap of SADS scaled scores between patient groups, consistent with a heterogeneous clinical presentation of depressive and anxiety states.
A comparative trial of the antidepressant, anxiolytic, and cardiovascular effects of trimipramine and doxepin in depressed hospitalized patients.
TLDR
Comparisons over time revealed that both drugs improved patients' overall well-being as indicated by the rating scales studied, and the total number of side effects reported was greater in the doxepin-treated patients.
Imipramine and chlordiazepoxide in depressive and anxiety disorders. II. Efficacy in anxious outpatients.
TLDR
Excluding patients with possible panic-phobic syndromes from the analyses removed most significant antiphobic and antidepressant effects of imipramine but left intact imipramsine's significantly superior antianxiety effects.
Trimipramine and maprotiline: antidepressant, anxiolytic, and cardiotoxic comparison.
TLDR
Both groups showed significant improvement over time, with no difference between the groups on the Severity and Improvement factors of the Clinical Global Impression scale, on the total and factor subscales of the Hamilton Depression Rating Scale, and on the Anxiety Status Inventory.
Studies in the classification of affective disorders. The relationship between anxiety states and depressive illnesses. I.
TLDR
Systematic comparison of the patients with anxiety states and depressive illness indicated that, with the aid of a wide range of items drawn from an adequate span of early life, personality and clinical features, a satisfactory degree of separation could be achieved, and confirmed that within an affective material there are two distinct syndromes corresponding to anxiety and depression.
Trimipramine, a tricyclic antidepressant exerting atypical actions on the central noradrenergic system.
TLDR
The results demonstrate that the down-regulation of central noradrenergic sensitivity in the rat is not a prerequisite for clinical efficacy of antidepressants in man.
Effects of Iproniazid in Depressive Syndromes
TLDR
In patients with lesions of the frontal lobes and in some psychotic states, the authors find a condition of postural plasticity in which an attitude imposed by passive movement is maintained indefinitely, or the patient may remain spontaneously immobilized in the same attitude for a long time.
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