Trimipramine, Anxiety, Depression and Sleep

  title={Trimipramine, Anxiety, Depression and Sleep},
  author={John C. Pecknold and Lorenz Luthe},
SummaryThe presence of mixed symptoms of anxiety and depression are well known to every clinician. Panic, generalised anxiety and obsessive-compulsive disorder all have considerable overlap with major depressive illness. Factor analysis of anxiety and depression symptoms has sought to predict response to treatment as well as to establish a diagnosis. Sleep disturbances are important concomitants of both syndromes. The analysis of the architecture and phasing of sleep stages has been proposed as… 
1 Citations
Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning.
It is demonstrated that moderate trimipramine poisoning can already occur after ingestion of doses in the high therapeutic range, and poisoned patients have to be monitored for central nervous system depression, dysrhythmias and QT(c) prolongation.


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  • Psychology, Medicine
    The Psychiatric clinics of North America
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The data demonstrate that antidepressants may vary in their effects on sleep, even though they have similar effects on depression; REM sleep suppression does not necessarily accompany improvement in depression; and reports of improved sleep by patients undergoing antidepressant therapy may not reflect improvement on objective measures of sleep.
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The use of biological markers in differentiating between clinical syndromes confounded by mixed or overlapping phenomenology is highlighted, and there was considerable overlap of SADS scaled scores between patient groups, consistent with a heterogeneous clinical presentation of depressive and anxiety states.
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