Trimethyltin disrupts N1 sensitivity, but has limited effects on the summating potential and cochlear microphonic.

@article{Fechter1994TrimethyltinDN,
  title={Trimethyltin disrupts N1 sensitivity, but has limited effects on the summating potential and cochlear microphonic.},
  author={Laurence D. Fechter and Ying Liu},
  journal={Hearing research},
  year={1994},
  volume={78 2},
  pages={189-96}
}
Trimethyltin (TMT), a model neurotoxicant, has previously been demonstrated to disrupt auditory thresholds in laboratory subjects. In this experiment we characterized the potency of this ototoxicant by means of a dose response study and then evaluated the functional effects of TMT administration when tone-bursts were presented at supra-threshold levels. Guinea pigs were anaesthetized and prepared for electrophysiological measurement of the compound action potential (CAP) and cochlear… CONTINUE READING

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