Trimethylaminuria, fish odour syndrome: a new method of detection and response to treatment with metronidazole

@article{Treacy2004TrimethylaminuriaFO,
  title={Trimethylaminuria, fish odour syndrome: a new method of detection and response to treatment with metronidazole},
  author={E. Treacy and D. Johnson and J. Pitt and D. Danks},
  journal={Journal of Inherited Metabolic Disease},
  year={2004},
  volume={18},
  pages={306-312}
}
  • E. Treacy, D. Johnson, +1 author D. Danks
  • Published 2004
  • Chemistry, Medicine
  • Journal of Inherited Metabolic Disease
  • SummaryTrimethylaminuria is an autosomal recessive disorder involving deficientN-oxidation of the dietary-derived amine trimethylamine (TMA). TMA, a volatile tertiary amine, accumulates and is excreted in urine of patients with deficient TMA oxidase activity. Treatment strategies for this condition are limited. We report a new stable-isotope dilution method for rapid sequential analysis of TMA concentrations and the clinical and biochemical response to treatment with metronidazole. 
    36 Citations
    Fish odor syndrome: a case report of trimethylaminuria.
    • 6
    [Primary trimethylaminuria: the fish odor syndrome].
    Diagnosis and management of trimethylaminuria (FMO3 deficiency) in children
    • 64
    • PDF
    Trimethylaminuria (fish odor syndrome) related to the choline concentration of infant formula
    • 6
    Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients.
    • 56
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 19 REFERENCES
    The use of metronidazole in management of methylmalonic and propionic acidaemias
    • 33
    Trimethylaminuria in a girl with Prader-Willi syndrome and del(15)(q11q13).
    • 11
    Trimethylamine N-oxide synthesis: a human variant.
    • 56
    The fish odor syndrome. Trimethylaminuria.
    • 40
    An improved gas--liquid chromatographic method for analysis of trimethylamine in urine.
    • 6
    The fish odour syndrome.
    • 26
    • PDF
    Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.
    • N. Lomri, Q. Gu, J. Cashman
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1992
    • 57
    • PDF