Trimethylamine: metabolic, pharmacokinetic and safety aspects.

  title={Trimethylamine: metabolic, pharmacokinetic and safety aspects.},
  author={Marcus A Bain and Gianfranco Fornasini and Allan M. Evans},
  journal={Current drug metabolism},
  volume={6 3},
Trimethylamine (TMA) is a volatile tertiary aliphatic amine that is derived from the diet either directly from the consumption of foods containing TMA, or by the intake of food containing precursors to TMA such as trimethylamine-N-oxide (TMNO), choline and L-carnitine. Following oral absorption in humans, TMA undergoes efficient N-oxidation to TMNO, a reaction catalyzed by the flavin-containing monooxygenase (FMO) isoform 3 enzyme. TMNO subsequently undergoes excretion in the urine, although… CONTINUE READING
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