Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study

@article{Andersen2012TrimethoprimUI,
  title={Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study},
  author={Jon Traerup Andersen and Morten Petersen and Espen Jimenez‐Solem and Kasper Broedbaek and Elisabeth Anne Wreford Andersen and Nadia Lyhne Tr{\ae}rup Andersen and Shoaib Afzal and Christian Torp-Pedersen and Niels Keiding and Henrik Enghusen Poulsen},
  journal={Epidemiology and Infection},
  year={2012},
  volume={141},
  pages={1749 - 1755}
}
The antibiotic trimethoprim acts as a folate antagonist. [...] Key Method A nationwide cohort study including all women in Denmark with a registered pregnancy between 1997 and 2005 was conducted. We used nationwide registers to identify all women giving birth, having a record of miscarriage or induced abortion. Data on exposure to trimethoprim were obtained from the National Prescription Register.Expand
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Anti-infective Agents
  • S. Padberg
  • Medicine
    Drugs During Pregnancy and Lactation
  • 2015
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References

SHOWING 1-10 OF 41 REFERENCES
Neural tube defects in relation to use of folic acid antagonists during pregnancy.
TLDR
It is suggested that a number of FAAs may increase NTD risk, and they provide estimates of risk for selected drugs.
Folic acid antagonists during pregnancy and risk of birth defects.
TLDR
Folic acid antagonists, which include such common drugs as trimethoprim, triamterene, carbamazepine, phenytoin, phenobarbital, and primidone, may increase the risk not only of neural-tube defects, but also of cardiovascular defects, oral clefts, and urinary tract defects.
Population-based case control study of folic acid supplementation during pregnancy.
TLDR
The case control pair analysis showed a significant protection after folic acid supplementation during the critical period of cardiovascular defects, neural tube defects, cleft lip with or without cleft palate and posterior clefts palate.
Induced Abortion: An Overview for Internists
TLDR
The numbers and characteristics of women having abortions are described, the methods used, safety data is summarized, and how internists can help patients with referrals to abortion providers if requested are explained, and costs are described.
Spontaneous abortion: A prospective cohort study of younger women from the general population in Denmark. Validation, occurrence and risk determinants
TLDR
A high rate of spontaneous abortion is found in the present study and an acceptable agreement between information obtained by interview and register information is found, confirming that number of previous spontaneous abortions is a strong determinant, and data may also indicate a role of previous contraceptive habits.
Antiphospholipid Syndrome during pregnancy: the state of the art.
TLDR
This review aims to deter- mine the current state of the art of APS by investigating the knowledge achievements of recent years, to provide the most appropriate diagnostic and therapeutic management for pregnant women suffering from this syndrome.
Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation.
  • A. Czeizel
  • Biology, Medicine
    American journal of medical genetics
  • 1996
TLDR
Multivitamin supplementation appeared to result in a significant reduction in the rate of urinary tract abnormalities, mainly obstructive defects, and in the rates of sporadic cardiovascular malformations, mainly ventricular septal defects.
Multivitamin supplementation and risk of birth defects.
TLDR
The hypothesis that periconceptional vitamin supplementation may extend benefits beyond a reduction in NTD risk is supported, and it is not clear what nutrient or combination of nutrients might affect risk of other specific defects.
Periconceptional multivitamin use and the occurrence of conotruncal heart defects: results from a population-based, case-control study.
TLDR
Periconceptional multivitamin use is associated with a reduced risk for conotruncal defects, and these findings could have major implications for the prevention of these birth defects.
...
1
2
3
4
5
...