Trimethoprim, sulphamethoxazole, bacterial adhesion and polymorphonuclear leucocyte function.

Abstract

Culturing Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae in the presence of subinhibitory concentrations (1/4 MIC) of trimethoprim, sulphamethoxazole or their combination, resulted in reduced adherence of all the above strains. The number of phagocytosed bacteria pre-exposed to subinhibitory concentrations of the above antibiotics was not significantly changed, but a significant increase of bactericidal activity of the polymorphonuclear leucocytes was observed. Furthermore, filtrates of K. pneumoniae and P. mirabilis grown in the presence of trimethoprim alone or in combination with sulphamethoxazole induced an increased chemotactic response of human polymorphonuclear leucocytes.

Statistics

0100200300'00'02'04'06'08'10'12'14'16
Citations per Year

113 Citations

Semantic Scholar estimates that this publication has 113 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Emmanouilides1990TrimethoprimSB, title={Trimethoprim, sulphamethoxazole, bacterial adhesion and polymorphonuclear leucocyte function.}, author={C E Emmanouilides and P E Lianou and H P Bassaris and J T Papavassiliou}, journal={The Journal of antimicrobial chemotherapy}, year={1990}, volume={26 6}, pages={803-12} }