Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial

@inproceedings{Chetchotisakd2014Trimethoprimsulfamethoxazole,
  title={Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial},
  author={Ploenchan Chetchotisakd and Wirongrong Chierakul and Wipada Chaowagul and Siriluck Anunnatsiri and Kriangsak Phimda and Piroon Mootsikapun and Seksan Chaisuksant and Jiraporn Pilaikul and Bandit Thinkhamrop and Sunchai Phiphitaporn and Wattanachai Susaengrat and Chalongchai Toondee and Surasakdi Wongrattanacheewin and Vanaporn Wuthiekanun and Narisara Chantratita and Janjira Thaipadungpanit and Nicholas P J Day and Direk Limmathurotsakul and Sharon J Peacock},
  booktitle={The Lancet},
  year={2014}
}
BACKGROUND Melioidosis, an infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, is difficult to cure. Antimicrobial treatment comprises intravenous drugs for at least 10 days, followed by oral drugs for at least 12 weeks. The standard oral regimen based on trial evidence is trimethoprim-sulfamethoxaxole (TMP-SMX) plus doxycycline. This regimen is used in Thailand but is associated with side-effects and poor adherence by patients, and TMP-SMX alone is recommended in… CONTINUE READING
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