Trimethoprim: Prediction of serum concentrations from saliva measurements

Abstract

Saliva has been used in the past as a non-invasive predictor of serum drug concentration. Prediction may be made from a regression line of saliva versus serum concentration or from an equation proposed by Matin et al. (1974); such predictions have been examined for trimethoprim, a drug that has a pKa of 7.3, the degree of ionisation influencing its… (More)
DOI: 10.1007/BF00607960

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