Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group.

@article{Dtry1994TrimetazidineAN,
  title={Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group.},
  author={J M D{\'e}try and Philippe Sellier and S Pennaforte and Dennis F Cokkinos and Henry G Dargie and Peter Mathes},
  journal={British journal of clinical pharmacology},
  year={1994},
  volume={37 3},
  pages={279-88}
}
1. Trimetazidine has a direct anti-ischaemic effect on the myocardium without altering the rate x pressure product or coronary blood flow. 2. The effects of trimetazidine (20 mg three times daily) were compared with those of propranolol (40 mg three times daily) in a double-blind parallel group multicentre study in 149 men with stable angina. 3. Reproducibility of exercise performance was verified during a 3 week run-in placebo washout period. All patients had > 1 mm ST-depression on exercise… CONTINUE READING

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