Trimeric structure for an essential protein in L1 retrotransposition.

  title={Trimeric structure for an essential protein in L1 retrotransposition.},
  author={Sandra L Martin and Dan Branciforte and David R. Keller and David L. Bain},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 24},
Two proteins are encoded by the mammalian retrotransposon long interspersed nuclear element 1 (LINE-1 or L1); both are essential for retrotransposition. The function of the protein encoded by the 5'-most ORF, ORF1p, is incompletely understood, although the ORF1p from mouse L1 is known to bind single-stranded nucleic acids and function as a nucleic acid chaperone. ORF1p self-associates by means of a long coiled-coil domain in the N-terminal region of the protein, and the basic, C-terminal region… CONTINUE READING
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