Trimeric interactions of the invariant chain and its association with major histocompatibility complex class II alpha beta dimers.

@article{Newcomb1996TrimericIO,
  title={Trimeric interactions of the invariant chain and its association with major histocompatibility complex class II alpha beta dimers.},
  author={John R. Newcomb and C Carboy-Newcomb and Peter Cresswell},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 39},
  pages={24249-56}
}
The invariant chain (I chain) associates with major histocompatibility complex class II alphabeta heterodimers upon synthesis, preventing them from binding peptides and unfolded proteins in the endoplasmic reticulum and directing class II transport to post-Golgi endosomal compartments. To assess which regions of the I chain are involved in binding class II molecules, we have studied proteolytic fragments of the I chain generated both by natural proteolytic degradation of alphabeta dimer… CONTINUE READING

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