Trimeric G protein-dependent signaling by Frizzled receptors in animal development.

  title={Trimeric G protein-dependent signaling by Frizzled receptors in animal development.},
  author={Diane Egger-Adam and Vladimir L Katanaev},
  journal={Frontiers in bioscience : a journal and virtual library},
Receptors of the Frizzled family transduce important signals during animal development and are conserved from sponges to humans. Frizzled receptors belong to the superfamily of G protein-coupled receptors (GPCRs), but until recently were considered G protein-independent in their signaling. In the present article we review the extensive knowledge demonstrating the functions of trimeric G proteins in Frizzled signal transduction in vertebrates and lower animals. Other structural and functional… CONTINUE READING


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Antagonistic Frizzled Transduction Pathways in Drosophila Planar Cell Polarity

  • V. L. Katanaev, D. Egger-Adam, A. Tomlinson
  • manuscript in preparation
  • 2008
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