Trimellitic anhydride-induced allergic response in the lung: role of the complement system in cellular changes.

@article{Fraser1995TrimelliticAA,
  title={Trimellitic anhydride-induced allergic response in the lung: role of the complement system in cellular changes.},
  author={Daniel G Fraser and Jean F Regal and Manuela Arndt},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={273 2},
  pages={793-801}
}
Trimellitic anhydride (TMA) is a small molecular weight industrial compound that will cause asthma-like symptoms in humans. Some of these TMA-induced symptoms can be reproduced in the guinea pig. In the guinea pig model of TMA-induced asthma, intratracheal instillation of TMA coupled to guinea pig serum albumin causes an immediate bronchoconstriction and increase in airway microvascular leakage with concomitant decrease in circulating platelets and white blood cells and subsequent cellular… CONTINUE READING
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