Trimebutine as a modulator of gastrointestinal motility.

@article{Lee2011TrimebutineAA,
  title={Trimebutine as a modulator of gastrointestinal motility.},
  author={Hyun-Tai Lee and Byung Joo Kim},
  journal={Archives of pharmacal research},
  year={2011},
  volume={34 6},
  pages={861-4}
}
Trimebutine has been used for treatment of both hypermotility and hypomotility disorders of the gastrointestinal (GI) tract, such as irritable bowel syndrome. In this issue, Tan et al. (2011) examined the concentration-dependent dual effects of trimebutine on colonic motility in guinea pig. The authors suggested that trimebutine attenuated colonic motility mainly through the inhibition of L-type Ca(2+) channels at higher concentrations, whereas, at lower concentrations, it depolarized membrane… CONTINUE READING

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Trimebutine has been used for treatment of both hypermotility and hypomotility disorders of the gastrointestinal ( GI ) tract , such as irritable bowel syndrome .
Trimebutine has been used for treatment of both hypermotility and hypomotility disorders of the gastrointestinal ( GI ) tract , such as irritable bowel syndrome .
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