Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells.

@article{Takizawa2010TrilostaneAI,
  title={Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells.},
  author={I. Takizawa and T. Nishiyama and N. Hara and T. Hoshii and F. Ishizaki and Y. Miyashiro and K. Takahashi},
  journal={Cancer letters},
  year={2010},
  volume={297 2},
  pages={
          226-30
        }
}
  • I. Takizawa, T. Nishiyama, +4 authors K. Takahashi
  • Published 2010
  • Chemistry, Medicine
  • Cancer letters
  • The intracellular androgen metabolism and cell activity in prostate cancer cells with mutated (LNCaP-FGC) or wild-type (VCaP) androgen receptors in the presence of trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, were examined. Trilostane suppressed the intracellular production of androstenedione, testosterone, and dihydrotestosterone from dehydroepiandrosterone in LNCaP-FGC cells. In both LNCaP-FGC and VCaP cell types, the prostate-specific antigen (PSA) levels in media were… CONTINUE READING
    10 Citations
    The CXCL12/CXCR4 axis promotes ligand-independent activation of the androgen receptor
    • 35
    Paradigm Shift in the Concept of Hormonal Milieu of Prostate Cancer
    • 1
    • PDF
    Sex Steroids and Gene Variants in Bipolar Disorder
    Deep learning with feature embedding for compound-protein interaction prediction
    • 32
    • PDF

    References

    SHOWING 1-10 OF 29 REFERENCES
    Trilostane in advanced breast cancer
    • 10
    • Highly Influential
    Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: Up-regulation of oestrogen receptor beta
    • 10
    Science behind total androgen blockade: from gene to combination therapy.
    • 103
    Non‐competitive steroid inhibition of oestrogen receptor functions
    • 35
    Role of 17β-Hydroxysteroid Dehydrogenases in Sex Steroid Formation in Peripheral Intracrine Tissues
    • 139
    Intracrinology of estrogens and androgens in breast carcinoma
    • 77