Triiodothyronine restricts myofibrillar growth and enhances beating frequency in cultured adult rat cardiomyocytes

@article{Schaub1998TriiodothyronineRM,
  title={Triiodothyronine restricts myofibrillar growth and enhances beating frequency in cultured adult rat cardiomyocytes},
  author={M. Schaub and M. A. Hefti and B. A. Harder and H. Eppenberger},
  journal={Basic Research in Cardiology},
  year={1998},
  volume={93},
  pages={391-395}
}
  • M. Schaub, M. A. Hefti, +1 author H. Eppenberger
  • Published 1998
  • Biology, Medicine
  • Basic Research in Cardiology
  • Abstract Adult rat cardiomyocytes (ARC) isolated from ventricles follow a defined sequence of structural remodeling during culturing for 2–3 weeks. Rod-shaped cells round up, attach to the substratum, and start growing out in all directions until they form contacts with one another and resume rhythmic contractile activity. In general, myofibrils redevelop along the actin scaffold into the periphery. IGF-I enhances this process while bFGF restricts the outgrowing of myofibrils to the central… CONTINUE READING
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