Triiodothyronine mimics the effects of estrogen in breast cancer cell lines.

  title={Triiodothyronine mimics the effects of estrogen in breast cancer cell lines.},
  author={C{\'e}lia Regina Nogueira and Maria Mitzi Brentani},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={59 3-4},
MCF-7 (estrogen receptor positive--ER+) and MDA-MB-231 (estrogen receptor negative--ER-) are human breast cancer cell lines which express functional thyroid hormone receptors (c-erb A alpha1 and c-erb beta1) as indicated by stimulation of mitochondrial alpha-glycerophosphate dehydrogenase. In MCF-7, mimicking E2, T3 stimulated growth in a dose-dependent (10(10) M - 10(-8) M) manner, induced the expression of progesterone receptor and growth factor TGFalpha mRNAs and inhibited that of TGFbeta… CONTINUE READING
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