Triiodothyronine levels in athyreotic individuals during levothyroxine therapy.

@article{Jonklaas2008TriiodothyronineLI,
  title={Triiodothyronine levels in athyreotic individuals during levothyroxine therapy.},
  author={Jacqueline Jonklaas and Bruce Davidson and Supna Bhagat and Steven John Soldin},
  journal={JAMA},
  year={2008},
  volume={299 7},
  pages={769-77}
}
CONTEXT Thyroidal production of triiodothyronine (T3) is absent in athyreotic patients, leading to the suggestion that T3 deficiency may be unavoidable during levothyroxine (LT4) therapy. However, trials evaluating therapy with combined LT4 and T3 have failed to demonstrate any consistent advantage of combination therapy. OBJECTIVE To determine whether T3 levels in patients treated with LT4 therapy were truly lower than in the same patients with native thyroid function. DESIGN, SETTING, AND… CONTINUE READING
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