Triiodothyronine improves left ventricular function without oxygen wasting effects after global hypothermic ischemia.

@article{Klemperer1995TriiodothyronineIL,
  title={Triiodothyronine improves left ventricular function without oxygen wasting effects after global hypothermic ischemia.},
  author={John D. Klemperer and John A. Zelano and Robert E. Helm and Kevin Berman and Kaie Ojamaa and Irwin L Klein and Ottis Wayne Isom and Karl H. Krieger},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={1995},
  volume={109 3},
  pages={
          457-65
        }
}
Cardiopulmonary bypass results in a "euthyroid sick" state. Recently, interest has focused on the relationship between low serum triiodothyronine levels and postoperative cardiovascular hemodynamics. The present study was undertaken to more clearly define the acute effects of triiodothyronine on myocardial mechanics and energetics after hypothermic global ischemia using an ex-vivo canine heart preparation to model the clinical condition. Experiments were performed on isolated hearts subjected… CONTINUE READING
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