Triiodothyronine (T3) induces HIF1A and TGFA expression in MCF7 cells by activating PI3K.

  title={Triiodothyronine (T3) induces HIF1A and TGFA expression in MCF7 cells by activating PI3K.},
  author={Fernanda Cristina Fontes Moretto and Maria Teresa de S{\'i}bio and Aline Carbonera Luvizon and Regiane M C Olimpio and Miriane de Oliveira and Carlos Augusto Barnab{\'e} Alves and Sandro Jos{\'e} Conde and C{\'e}lia Regina Nogueira},
  journal={Life sciences},
High expression levels of hypoxia inducing factor 1 alpha are related to mammary carcinogenesis. In previous studies, we demonstrated that expression of transforming growth factor alpha increases upon treatment with triiodothyronine, but this expression does not occur in cellular models that do not express the estrogen receptor, or when cells are co-treated with the anti-estrogen, tamoxifen. The aim of this study was to determine the effect of the hormone triiodothyronine on the expression of… CONTINUE READING
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N. B. Figueiredo, S. H. Cestari, S. J. Conde, R. A. Luvizotto, M. T. De Sibio
Perone, et al., Estrogen-responsive genes overlap with triiodothyronine-responsive genes in a breast 1 carcinoma cell line, Sci. World J. 969404 • 2014


H. Y. Lin, M. Sun, H. Y. Tang
Lin, M.K. Luidens, S.A. Mousa, et al., L-Thyroxine vs. 3,5,3′-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase, Am. J. Phys. Cell Physiol. 296 • 2009

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