Triidothyronine-induced reversal of learned helplessness in rats

  title={Triidothyronine-induced reversal of learned helplessness in rats},
  author={P. Martin and Denis Brochet and Philippe Soubrié and Pierre Simon},
  journal={Biological Psychiatry},

Strong interactions between learned helplessness and risky decision-making in a rat gambling model

Results suggest that while baseline risky decision making may not predict LH behaviour it interacts strongly with LH conditions in modulating subsequent decision-making behaviour, and the suggested possibility that stress controllability may be a key factor should be further investigated.

Active behavioral coping alters the behavioral but not the endocrine response to stress

Effect of Triiodothyronine on Antidepressant Screening Tests in Mice and on Presynaptic 5-HT1A Receptors: Mediation by Thyroid Hormone α Receptors

Blockade by dronedarone of the antidepressant-like effects of T3 suggests that these effects are TRα receptor-mediated, and suggests a possible gender disparity in the role of presynaptic 5-HT1A receptors in T3 antidepressant mechanisms.

Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior.

These results provide the first direct evidence that the endogenous TRH system is involved in mood regulation, and this function is carried out through TRH-R1-mediated neural pathways.

Antidepressant-like effects of triiodothyroacetic acid in mice

TA3 was effective on the same psychopharmacological tests which have previously been used to demonstrate the antidepressant-like effects of T3, and might, therefore, be preferable to T3 for clinical use in depression.

Thyroid Hormones in Depressive Disorders: A Reappraisal of Clinical Utility

Research findings include an association of subclinical hypothyroidism with unsatisfactory responses to antidepressant treatment, evidence that triiodothyronine and thyroid‐stimulating hormone may speed recovery in acute depression, and limited and inconsistent support for the effectiveness of exogenous thyroid hormones to augment antidepressants.



Receptor sensitivity and the mechanism of action of antidepressant treatment. Implications for the etiology and therapy of depression.

The effects of long-term antidepressant treatment on biogenic amine metabolism and on various indexes of presynaptic and postsynaptic receptor function are evaluated to provide support for hypotheses of amine receptor abnormalities in depression and indicate the need for expanded studies ofAmine receptor function in patients.

Potentiation of antidepressant effects by L-triiodothyronine in tricyclic nonresponders.

Six women and 6 men who were treated in double-blind fashion major depressive illness did not respond to imipramine or amitriptyline, 150-300 mg/day, but after the addition of L-triiodothyronine (T3), 9 patients showed statistically significant improvement in depression scores.

Learned helplessness decreases [3H]imipramine binding in rat cortex.

Normal thyroid function in desipramine nonresponders converted to responders by the addition of L-triiodothyronine.

The results of complete thyroid function testing were normal in four desipramine nonresponders who were converted to responders by addition of L-triiodothyronine (T3). These findings suggest that the